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Valentina Greco, PhD
Carolyn Slayman Professor of Genetics
Yale University School of Medicine
Yale Stem Cell Center
Yale Cancer Center
333 Cedar Street, SHM I 336B
New Haven, CT 06520



Press Coverage about our Publications


Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S & Greco V✉. Hair follicle regeneration suppresses Ras-driven oncogenic growth. Journal of Cell Biology, 2019 Sept 5 Online.

New hair follicles can corral skin cancer

Marsh E, Gonzalez DG, Lathrop EA, Boucher J and Greco V✉. Positional stability and membrane occupancy define skin fibroblast homeostasis in vivo. Cell. 2018 Nov 8;175(6):1620-1633.

Revitalizing Aging Skin through Diet

Mesa K*, Kawaguchi K*, Cockburn K*✉, Gonzalez DG, Boucher J, Xin T, Klein AM✉ and Greco V✉. Homeostatic stem cell self-renewal is driven by local differentiation. Cell Stem Cell. 2018 Nov 1;.23:1-10.

Neighbors hold key to the renewal of stem cells

Brown S*, Pineda CM*, Xin T, Boucher J, Suozzi KC, Park S, Matte-Martone C, Gonzalez DG, Rytlewski J, Beronja S✉ and Greco V✉. Correction of aberrant growth preserves tissue homeostasis. Nature. 2017 Aug 17;548:334-337.

Policing Tumorigenesis within the Skin: Good Outs Bad

Cell biology: Healthy skin rejects cancer

Good cellular neighbors combat incipient cancers


Rompolas P*, Mesa KR*, Kawaguchi K, Park S, Gonzalez D, Brown D, Boucher J, Klein AM✉ and Greco V✉. Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Science. 2016 Jun 17;352(6292):1471-4

Fate by Chance, not by Choice: Epidermal Stem Cells Go Live

Research note: Images show how stem cells create just enough tissue

Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez D, Blagoev K, Haberman A and Greco V✉.  Niche induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature. 2015 Jun 4;522(7554):94-7

Research in the News: Tiny hair follicle offers big clues about the life and death of stem cells

Follicle Stem Cells Done in by Neighbors

Deschene RE*, Myung P*, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I and Greco V✉. β-catenin activation regulates tissue growth via a non-cell autonomous mechanism within the hair stem cell niche. Science. 2014 Mar 21;343(6177):1353-6

A key link between tumors and healthy tissue identified

Rompolas P, Mesa KR and Greco V✉. Spatial organization within a niche as a determinant of stem cell fate. Nature. 2013 Oct 24;522(7472):513-8

In stem cells, like real estate, location is most important factor

Rompolas P, Deschene ER, Zito G, Gonzalez DG, Saotome I, Haberman AM and Greco V✉. Live imaging of stem cell and progeny behavior in physiological hair follicle regeneration. Nature. 2012 Jul 26;487(7408):496-9

Reporting Live from the Epidermal Stem Cell Compartment!

In real time, Yale scientists watch stem cells at work regenerating tissue


Pantelis Rompolas

2014 Blavatnik Awards