Tissue regeneration is an extremely dynamic process, requiring coordination of many cellular behaviors, including self-renewal and differentiation, to maintain normal tissue function. In an organ like the skin tissues are physically in close proximity and have to coordinate their actions to maintain distinct identities. By investigating homeostatic principles that maintain different tissue types within an organ we can begin to elucidate sufficiency and requirements of specific tissues towards maintaining overall organ function.
HISTORY -> XIN
Utilizing our novel live imaging approach we discovered that stem cells have incredible plasticity during homeostasis (Xin, 2018) and that, most importantly, this plasticity is an embedded property of our tissues and not an emerging property of a pathological or injury state.
2) position dictates stem cell fate (Rompolas*, Mesa*, 2016) and that direct neighbors coordinate their fate decisions (Mesa*, Kawaguchi*, Cockburn*, 2018).