PUBLICATIONS

2024

The art of observation: bridging science and art to see the unexpected. Gonzalez LE, Wei H, Greco V, Friedlaender LK. Development. Mar 1, 2024. doi.org/10.1242/dev.202786

2023

Organ function is preserved despite reorganization of niche architecture in the hair follicle. Wei H, Du S, Parksong J, Pasolli HA, Matte-Martone C, Regot S, Gonzalez LE, Xin T✉ & Greco V✉. Cell Stem Cell. Jul 6, 2023. doi.org/10.1016/j.stem.2023.06.003 [bioRxiv]

Injury prevents Ras mutant cell expansion in mosaic skin. Gallini S, Annusver K, Rahman N, Gonzalez DG, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi KC, Kasper M✉ & Greco V✉. Nature. Jun 21, 2023. doi.org/10.1038/s41586-023-06198-y [bioRxiv]

A Spatiotemporal Compartmentalization of Glucose Metabolism Guides Mammalian Gastrulation Progression. Cao D, Zhong L, Hemalatha A, Bergmann J, Cox AL, Greco V & Sozen B✉. bioRxiv. Jun 8, 2023. doi.org/10.1101/2023.06.06.543780

Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Sola P, Solanas G, Bonjoch J, Marsh ED, Hirschi KK✉ & Greco V✉. Cell. May 25, 2023. doi.org/10.1016/j.cell.2023.04.017 [bioRxiv]

Cell cycle controls long-range calcium signaling in the regenerating epidermis. Moore J*, Bhaskar D*, Gao F*, Matte-Martone C, Du S, Lathrop E, Ganesan S, Shao L, Norris R, Sanz NC, Annusver K, Kasper M, Cox A, Hendry C, Rieck B, Krishnaswarmy S✉ & Greco V✉. Journal of Cell Biology. Apr 27, 2023. doi.org/10.1083/jcb.202302095 [bioRxiv]

Capturing Spatiotemporal Signaling Patterns in Cellular Data with Geometric Scattering Trajectory Homology. Bhaskar D, Moore JL, Gao F, Rieck B, Khasawneh F, Munch E, Greco V & Krishnaswamy S✉. bioRxiv. Mar 24, 2023. doi.org/10.1101/2023.03.22.533807

Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo. May D*, Yun S*, Gonzalez DG, Park S, Chen Y, Lathrop E, Cai B, Xin T, Zhao H, Wang S, Gonzalez LE✉, Cockburn K✉ & Greco V✉. eLife. Mar 20, 2023. doi.org/10.7554/eLife.83444 [bioRxiv]

2022

Susan L. Solomon (1951–2022): Advocate, Innovator, Catalyst. Fossati V, Greco V, Arlotta P & Aiyar RS✉. Stem Cell Reports. Dec 13, 2022. doi.org/10.1016/j.stemcr.2022.11.013

Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermis in vivo. Hemalatha A, Li Z, Tai K, Gonzalez DG, Lathrop E, Gil D, Matte-Martone C, Ganesan S, Yun S, Gonzalez LE, Skala M, Perry RJ✉ & Greco V✉. bioRxiv. Nov 23, 2022. doi.org/10.1101/2022.11.21.517380

Double knockin mice show NF-kB trajectories in immune signaling and aging. Rahman S, Aqdas M, Martin EW, Ardori FT, Songkiatisak P, Oh K, Uderhardt S, Yun S, Claybourne QC, McDevitt RA, Greco V, Germain RN, Tessarollo L, & Sung M✉. Cell Reports. Nov 22, 2022. doi.org/10.1016/j.celrep.2022.111682

Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer. Cockburn K, Annusver K, Gonzalez DG, Ganesan S, May DP, Mesa KR, Kawaguchi K, Kasper M✉ & Greco V✉. Nature Cell Biology. Nov 10, 2022. doi.org/10.1038/s41556-022-01021-8 [bioRxiv]

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation. Xin T, Gallini S, Gonzalez D, Gonzalez LE, Regot S✉ & Greco V✉. bioRxiv. Sept 17, 2022. doi.org/10.1101/2022.09.14.507992

Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks. Yamamoto T✉, Katie Cockburn K, Greco V & Kawaguchi K✉. PLOS Computational Biology. Sept 6, 2022. doi.org/10.1371/journal.pcbi.1010477 [bioRxiv]

A group approach to growing as a principal investigator. Greco V✉, Politi K✉, Eisenbarth S✉, Colón-Ramos D✉, Giraldez AJ✉, Bewersdorf J✉ & Berg DN✉. Current Biology. Jun 6, 2022. doi.org/10.1016/j.cub.2022.04.082

From start to finish—a molecular link in wound repair. Yun S & Greco V✉. Science. Feb 11, 2022. doi.org/10.1126/science.abn7411

2021

Functional cell death, corneoptosis, requires temporally controlled intracellular acidification. Moore J✉ & Greco V✉. PNAS. Jun 1, 2021. doi.org/10.1073/pnas.2106633118

Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis. Park S*, Matte-Martone C*, Gonzalez DG, Lathrop EA, May DP, Pineda CM, Moore JL, Boucher JD, Marsh ED, Schmitter A, Cockburn K, Markova O, Bellaiche Y, Greco V✉. Nature Cell Biology. May 6, 2021. doi.org/10.1038/s41556-021-00670-5 [bioRxiv]

3D Super-Resolution Deep Tissue Imaging in Live Mice. Velasco MG, Zhang M, Antonello J, Yuan P, Allgeyer E, May DP, M’Saad O, Kidd P, Barentine A, Greco V, Grutzendler J, Booth M & Bewersdorf J✉. Optica. Mar 25, 2021. doi.org/10.1364/OPTICA.416841

2020

Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo. Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V & Regot S✉. Developmental Cell. Oct 21, 2020. doi.org/10.1016/j.devcel.2020.09.013

2019

Hair follicle regeneration suppresses Ras-driven oncogenic growth. Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S & Greco V✉. Journal of Cell Biology. Oct 7, 2019. doi.org/10.1083/jcb.201907178

Lymph vessels find a hairy niche. Kam CY✉ & Greco V✉. The EMBO Journal. Sept 17, 2019. doi.org/10.15252/embj.2019103219

Suzanne Eaton: 1959–2019. Greco V✉ & Ghosh S✉. Nature Cell Biology. Aug 22, 2019. doi.org/10.1038/s41556-019-0387-1

Flexibility sustains epithelial tissue homeostasis. Tai K, Cockburn K✉ and Greco V✉. Current Opinion in Cell Biology. May 29, 2019. doi.org/10.1016/j.ceb.2019.04.009

NEWS

New hair follicles can corral skin cancer - Yale News. Sep 5, 2019

Remembering Carolyn W. Slayman - Yale Medicine. Apr 9, 2019

Scientist finds skin deep is very deep - Yale Medicine. Feb-Mar, 2019

Stem Cell Collection 2020 - Rockefeller University Press. 2019

2018

Flexible fate determination ensures robust differentiation in the skin hair follicle. Xin T, Gonzalez DG, Rompolas P and Greco V✉. Nature Cell Biology. Nov 12, 2018. doi.org/10.1038/s41556-018-0232-y

Positional stability and membrane occupancy define skin fibroblast homeostasis in vivo. Marsh E, Gonzalez DG, Lathrop EA, Boucher J and Greco V✉. Cell. Nov 8, 2018. doi.org/10.1016/j.cell.2018.10.013

Homeostatic stem cell self-renewal is driven by local differentiation. Mesa K*, Kawaguchi K*, Cockburn K*✉, Gonzalez DG, Boucher J, Xin T, Klein AM✉ and Greco V✉. Cell Stem Cell. Nov 1, 2018. doi.org/10.1016/j.stem.2018.09.005

2017

Correction of aberrant growth preserves tissue homeostasis. Brown S*, Pineda CM*, Xin T, Boucher J, Suozzi KC, Park S, Matte-Martone C, Gonzalez DG, Rytlewski J, Beronja S✉ and Greco V✉. Nature. Aug 17, 2017. doi.org/10.1038/nature23304

Tissue-scale coordination of cellular behavior promotes epidermal wound repair in live mice. Park S, Gonzalez D, Guirao B, Boucher J, Cockburn K, Marsh E, Mesa K, Brown S, Rompolas P, Haberman A, Bellaïche Y and Greco V✉. Nature Cell Biology. Mar 1, 2017. doi.org/10.1038/ncb3472

Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers. Sun, T✉, Haberman A and Greco V✉. Journal of Investigative Dermatology. Feb 1, 2017. doi.org/10.1016/j.jid.2016.08.033

2016

The thrill of scientific discovery and leadership with my group. Greco V✉. Molecular Biology of the Cell. Nov 1, 2016. doi.org/10.1091/mbc.E16-06-0373

Live imaging of stem cells: answering old questions and raising new ones. Park S, Greco V✉, and Cockburn K✉. Current Opinion in Cell Biology. Jul 27, 2016. doi.org/10.1016/j.ceb.2016.07.004

Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Rompolas P*, Mesa KR*, Kawaguchi K, Park S, Gonzalez D, Brown S, Boucher J, Klein AM✉ and Greco V✉. Science. Jun 17, 2016. doi.org/10.1126/science.aaf7012

Hardwiring Stem Cell Communication through Tissue Structure. Xin T, Greco V✉ and Myung P✉. Cell. Mar 10, 2016. doi.org/10.1016/j.cell.2016.02.041

2015

Intravital imaging of hair follicle regeneration in the mouse. Pineda CM*, Park S*, Mesa KR, Wolfel M, Gonzalez D, Haberman A, Rompolas P✉, and Greco V✉. Nature Protocols. Jul 10, 2015. doi.org/10.1038/nprot.2015.070

The dynamic duo: niche/stem cell interdependency. Mesa KR, Rompolas P and Greco V✉. Stem Cell Reports. Jun 9, 2015. doi.org/10.1016/j.stemcr.2015.05.001

Niche induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez D, Blagoev K, Haberman A and Greco V✉. Nature. Jun 4, 2015. doi.org/10.1038/nature14306

2014

Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging. Brown S and Greco V✉. Cell Stem Cell. Dec 4, 2014. doi.org/10.1016/j.stem.2014.11.006

Establishing an academic laboratory: mentoring as a business model. Greco V✉. Molecular Biology of the Cell. Nov 1, 2014. doi.org/10.1091/mbc.e14-06-1079

Spontaneous tumor regression in keratoacanthomas is driven by Wnt /Retinoic Acid signaling cross-talk. Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ and Greco V✉. Nature Communications. Mar 26, 2014. doi.org/10.1038/ncomms4543

β-catenin activation regulates tissue growth via a non-cell autonomous mechanism within the hair stem cell niche. Deschene RE*, Myung P*, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I and Greco V✉. Science. Mar 21, 2014. doi.org/10.1126/science.1248373

Stem cell dynamics in the hair follicle niche. Rompolas P✉ and Greco V✉. Seminars in Cell & Developmental Biology. Jan-Feb 2014. doi.org/10.1016/j.semcdb.2013.12.005

2013

Spatial organization within a niche as a determinant of stem cell fate. Rompolas P, Mesa KR and Greco V✉. Nature. Oct 24, 2013. doi.org/10.1038/nature12602

Linking morphogen and chromatin in the hair follicle. Mesa KR and Greco V✉. Developmental Cell. Apr 29, 2013. doi.org/10.1016/j.devcel.2013.04.009

The death and growth connection. Greco V✉. Nature Reviews Molecular Cell Biology. Jan 1, 2013. doi.org/10.1038/nrm3490

2012

Live imaging of stem cell and progeny behavior in physiological hair follicle regeneration. Rompolas P, Deschene ER, Zito G, Gonzalez DG, Saotome I, Haberman AM and Greco V✉. Nature. Jul 26, 2012. doi.org/10.1038/nature11218

2010

Compartmentalized organization: a common and required feature of stem cell niches? Greco V✉ and Guo S. Development. May 15, 2010. doi.org/10.1242/dev.041103

Pre-Greco Lab (2009 and earlier)

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration. Greco V*, Chen T*, Rendl M, Schober M, Pasolli HA, Stokes N, Cruz-Racelis JD and Fuchs E✉. Cell Stem Cell. Feb 6, 2009. doi.org/10.1016/j.stem.2008.12.009

Mice cloned from skin cells. Li J*, Greco V*, Guasch G*, Mombaerts P✉ and Fuchs E✉. PNAS. Feb 20, 2007. doi.org/10.1073/pnas.0611358104

Defining the epithelial stem cell niche in skin. Tumbar T, Guasch G, Greco V, Blanpain C, Lowry W, Rendl M and Fuchs E✉. Science. Jan 16, 2004. doi.org/10.1126/science.1092436

Argosomes: A Potential Vehicle for the Spread of Morphogens through Epithelia. Greco V, Hannus M and Eaton S✉. Cell. Sep 7, 2001. doi.org/10.1016/S0092-8674(01)00484-6

DNA re-replication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Di Leonardo A*, Hussain KS*, Linke SP, Greco V, Seidita G and Wahl GM✉. Cancer Research. Mar 1, 1997.