Stem Cells in Organ Regeneration

Every day our body makes and loses billions of cells. This continuous regeneration is sustained by the presence of stem cells, which act as a lifelong reservoir by their ability to self-renew and differentiate into all the different lineages of a tissue.  In the Greco lab our goal is to define how tissues maintain themselves throughout the course of our lives in the face of continuous cellular turnover, frequent injuries and spontaneous mutations.

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Despite the highly dynamic nature of this process, the field has been limited by the inability to track the same cells over time and interrogate their behaviors in a live mammal. To overcome this challenge, we have developed novel tools that integrate imaging of stem cells in their niche in live mice with genetics and cell biological approaches, allowing us to understand the complex orchestration of tissue regeneration using the skin as model system.